Sep 27, 2024

Subject:Breaking: Sanders says PBMs won’t penalize Novo for cutting Ozempic, Wegovy pricess((Sender:newsletter@statnews.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MTcyNzE5MTE3MzYyOC5lZGY5ZmVhZS1hNjA3LTRhY2ItYjg5Ni0zOTNkNGFlNDY5ZDJAYmY1MnguaHVic3BvdGVtYWlsLm5ldHx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1l569b45716c8ad81525a47b1cd58e75cbc((It’s Sanders’ latest move to pressure Novo to cut the prices of the blockbuster diabetes and obesity therapies | — Log In Subscribe — BREAKING NEWS — Sanders says PBMs won’t penalize Novo for cutting Ozempic, Wegovy prices — By Rachel Cohrs Zhang and Elaine Chen — — Kevin Dietsch/Getty Images — In a Senate health committee hearing today, Sen. Bernie Sanders said major drug middlemen have agreed not to limit coverage of Novo Nordisk’s Ozempic and Wegovy if the company lowers the prices of the treatments. It’s Sanders’ latest move to pressure Novo to cut the prices of the blockbuster diabetes and obesity therapies. — READ MORE — | Sign up for D.C. Diagnosis — Your essential briefing on health care politics and policy. Learn more. In Case You Missed It — 1 | Bernie Sanders may have reached the limits of his pharma pressure campaign Rachel Cohrs Zhang —|— 2 | Can amylin drugs best Wegovy and Zepbound? Companies bet on next big obesity target By Elaine Chen and Allison DeAngelis —|— 3 | The U.S. has relied on cheap, effective generic drugs for 40 years. Now that promise is under threat By Leslie Walker and Dan Gorenstein —|— 4 | Electronic health records giant Epic Systems sued over alleged monopolistic practices By Casey Ross —|— | — Don’t miss out on another STAT Investigation Unlock the world of health and medicine with a subscription to STAT+ Learn more | | — | — STAT, 1 Exchange Place, Boston, MA ©2024, All Rights Reserved. I no longer wish to receive STAT emails | Update Newsletter Preferences • Contact Us • Advertise with Us — Subject:🏥 Ascension’s Wild Years((Sender:hospitalogy@workweek.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MjAyNDA5MjQxODU3MDQuMzY4NDM0NTkuOTQ5OUBzYWlsdGhydS5jb218fGNrc20raGVhbHRoY2FyZUBzdW1teW1vbmtleS5tZQ==ec8ca231f56a137a44781482c1c81628c((How Ascension is redefining itself in 2024 | | | — | | PARTNERED WITH — — | | Happy Tuesday, Hospitalogists! Ascension recently reported their 2024 report and I thought it was worth looking into for you guys. Long story short, Ascension is in the midst of a rapid strategic shift as they look to exit undesirable markets and restructure the health system’s portfolio and associated assets around what’s working. To that end, I have a graphic with some brief commentary, and that’s it for today. Let’s dive in! — Was this email forwarded to you? — Subscribe Here — | | | — SPONSORED BY MEDALLION — How will private equity or AI reshape healthcare? Curious about what comes next? Drumroll, please… Medallion’s Elevate virtual conference is back on October 30, featuring industry leaders from VillageMD, Clover Health, and more. Get ahead of 2025’s challenges with insights on AI in care delivery, payer- provider collaborations, and the future of PE and VC in healthcare. Plus, Elevate’s celebrating its third year with a chance to win up to $2,000. Pull up a chair for fresh perspectives and actionable strategies. Secure your spot (and maybe win big)—completely free. — Sign up today! — | | | — # Ascension Healthcare’s Slow…er…re-Ascension: — — # Ascension’s recent, notable activity — 1. August 2024: Sold 3 hospitals and associated footprint to MyMichigan Health, exiting northern Michigan market. 2. July 2024: Sold 9 hospitals and associated footprint to Prime Healthcare, Prime’s largest acquisition to-date and reflecting Ascension’s further retreat from Chicago/Illinois market. 3. June 2024: Sold St. Vincent’s Health System in Alabama to UAB for ~$450M. 4. June 2024: Ascension Personalized Care (its ACA plan) exited Texas 5. May 2024: Ascension experiences system-wide cybersecurity incident. 6. March 2024: Sold certain Ascension Health senior care assets to Villa Investment Partners 7. February 2024: Transitioned Ascension Pittsburg to Mercy 8. February 2024: Transitioned Our Lady of Lourdes Memorial Hospital to The Guthrie Clinic 9. December 2023: Formed JV with Lifepoint Health to jointly own Highpoint Health System consisting of 3 hospitals & assets in Tennessee. 10. November 2023: Divested its 50% stake in Network Health to Froedtert Health giving Froedtert full ownership 11. October 2023: Formed a joint venture with Henry Ford Health System and contributed all Ascension southeast and mid Michigan hospitals to the JV. Ascension gets ownership % in HFHS. 12. October 2023: Sold Providence Hospital in Alabama to the University of South Alabama Health Care Authority. — # Why it matters — A big theme of 2024 is market density, and portfolio realignment. We’ve seen Tenet sell hospitals to an extreme degree, and Ascension is right there with ’em with some rapid exits from the Michigan and Illinois/Chicago markets. Not included above is Ascensions unwinding of its Amita Health JOA. It has been a long journey for Ascension. In fact the nonprofit probably would have swung from a $3B loss to profitable this year (including investment returns) had it not been for the May cybersecurity event stunting volume growth at a pivotal time. If the signal isn’t clear, it should be – these markets are unattractive, and Ascension didn’t have the right assets, market share, or strategy to continue sustainable operations. Therefore remaining players either are firmly entrenched and/or have an uphill battle against poor market demographics and strong payor presence. — I know the graphic is small, so here’s a closer look at that waterfall chart: — — Based on new ventures like Ascension One and where that’s being prioritized, you should expect to see Ascension bolster its presence in these types of markets with more attractive characteristics. It’s the healthcare game we play! — | | | — SPONSORED BY PEP HEALTH — Imagine running a hospital and relying on HCAHPS scores to gauge patient satisfaction—but the data comes too late and lacks real-time impact. This isn’t hypothetical. A Midwest health system managing 12 hospitals and 90 clinics faced a summer slump. Patient experience scores fell below the state average, threatening their reputation and finances. With the help of PEP Health’s AI-powered dashboard, they were able to analyze 1.3M+ reviews, pinpoint a lack of fast access as the issue, and reverse the decline. Now, they predict HCAHPS outcomes 9 months ahead, outperforming and staying ahead without burdening staff. Check out the case studies! Validating PEP Scores as a Leading Indicator of Hospital Performance Closing Patient Experience Gaps with PEP Health’s Dashboard — | | | — Thanks for the read! Let me know what you thought by replying back to this email. — Blake — | | | | — Share Hospitalogy, Earn Rewards Have friends who’d love Hospitalogy too? Click the link below to share Hospitalogy with your friends and earn awesome rewards! 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Why we can’t agree how to categorise the basic unit of lifes((Sender:briefing@nature.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MmM2MDU3YzUyOGZkYzZmNzNmYTE5NmQ5ZC5hYjk3NmZkMmZiLjIwMjQwOTI0MTc0MTEyLjY1ZTI3MzE3NDUuMmRkZGEyY2NAbWFpbDE3MS5zdXcxOC5yc2dzdi5uZXR8fGNrc20raGVhbHRoY2FyZUBzdW1teW1vbmtleS5tZQ==ed2ce55377777e629e7d930511bcdc14c((What matters in science | | View this email in your browser | Tuesday 24 September 2024 —|— | — Hello Nature readers, Today we learn that octopuses team up with fish to hunt for food, discover how an X-ray blast could divert an asteroid from hitting Earth and ponder: what is a cell type, really? In new footage, octopuses were seen punching ‘opportunistic’ fish, individuals that attached themselves to the hunting group but did not help them find food. (Eduardo Sampaio) ## Octopuses recruit help to hunt Octopuses and fish have been caught on camera teaming up to hunt for prey. Researchers caught 13 instances of the cross-species collaboration over 120 hours of footage, showing a big blue octopus (Octopus cyanea) working with different fish species to capture meals. Each of these scenes hinted at complex group dynamics, with different species adopting different roles. “The other fish provide several options, and then the octopus decides which one to take,” says animal-behaviour researcher and co-author Eduardo Sampaio. “There’s this element of shared leadership.” Nature | 3 min read Reference: Nature Ecology & Evolution paper ## X-rays could save Earth from an asteroid A blast of X-rays from a nuclear explosion should be enough to save Earth from an incoming asteroid, a first-of-its-kind experiment shows. Researchers recreated the scenario in miniature, firing X-rays at two 12-millimetre mock asteroids made of quartz and silica. In just 20 millionths of a second, the samples were accelerated to high speeds as the X-rays vaporized their surface, creating a thrust as gas expanded away from them. The results “showed some really amazing direct experimental evidence for how effective this technique can be”, says physicist Dawn Graninger. Nature | 4 min read Reference: Nature Physics paper ## Human heart tissue ages in space Over the course of just one month on the International Space Station, engineered human heart tissue got weaker, its ‘beating’ patterns became irregular and it underwent molecular and genetic changes that mimicked the effect of ageing. But the irregular beating disappeared after coming back to Earth. This suggests that space crew such as cosmonauts Oleg Kononenko and Nikolai Chub, who just completed the longest- ever stay in space, probably experience cardiovascular stress that resolves after they return to Earth. Nature | 3 min read & BBC | 1 min watch Reference: PNAS paper ## Budget cut hits National Cancer Institute The US National Cancer Institute (NCI), the world’s largest funder of cancer research, is grappling with a budget cut. The reduction leaves it US$96 million short of the previous year’s figure, with a reprieve in 2025 unlikely. The end of projects such as the Cancer Moonshot Initiative, supported by President Joe Biden, are largely responsible, but with grant applications up 40% over the last decade, the institute must make some difficult decisions, says NCI director Kimryn Rathmell. Nature | 4 min read | ## Features & opinion — (Top row: Steve Gschmeissner/SPL. Middle row, L: Thomas Deerinck, NCMIR/SPL; Centre and R: Steve Gschmeissner/SPL. Bottom row, L: Steve Gschmeissner/SPL; Centre: Alain Pol, ISM/SPL; R, Medimage/SPL.) ## What is a cell type, really? Ask a dozen researchers about how to group similar cells together and you’ll get as many different answers. Its function, response to its environment and which genes it switches on have all been suggested as the criteria we should use to categorise the basic unit of life. And the further we delve into cells of the same type, the more differences begin to appear between them. So, what exactly is a cell type? As biologist Barbara Treutlein puts it, “there’s a general consensus that it is extremely complicated”. Nature | 12 min read ## Girls’ education must be in Taliban talks Three years after the Taliban took over Afghanistan, women are locked out of post-primary education, banned from most jobs (including nearly all forms of research and teaching) and forbidden from even speaking or singing in public. The Taliban are not recognized as Afghanistan’s legitimate government, but relations are thawing — without the participation of women’s organizations or discussions of education. “Where is the outrage?” demands a Nature editorial. “This cannot continue. If it does, the international community will be complicit in gender apartheid.” Nature | 5 min read ## What dinosaurs don’t say about biodiversity Dinosaur taxonomy is tough: only a tiny fraction of animals are preserved as fossils and there is little genetic data to guide taxonomic discussions. Researchers have “barely have enough species to work with to allow a lot of our analyses to even run,” says palaeobiologist Emma Dunne. This makes it hard to know for sure how biodiversity has changed over time. “The actual numbers of species lost in previous environmental catastrophes are probably always worse than we currently record because we’re probably lumping more than one species under one name,” says palaeontologist Tom Holtz. Scientific American | 7 min read ## Quote of the day “Many evaluations remain buried in institutional vaults, inaccessible or unknown to many. Often, the reports are read by just a handful of people before being filed away.” Tens of thousands of studies evaluating government programmes are collecting dust in filing cabinets. World leaders must commit to opening up the vaults, argues a Nature editorial. (5 min read) | — | You can keep your fancy AIs and supercomputers — I’m entranced by the slime- mould algorithm. Physarum polycephalum, despite having no neurons, brain or subscription to Nature, has already proven itself to be a dab hand at coming up with efficient Tokyo subway networks and helping run a heart-rate- sensing smartwatch. Now an algorithm based on the brilliant blob has been used to simulate how the cosmic web of matter forms over unimaginable aeons. Help keep this newsletter growing towards its optimal state by sending us your feedback. Your e-mails are always welcome at briefing@nature.com. Thanks for reading, Flora Graham, senior editor, Nature Briefing With contributions by Jacob Smith and Smriti Mallapaty — | — ## Free newsletters from Nature Want more? Update your preferences to sign up to our other Nature Briefing newsletters: * Nature Briefing: Careers — insights, advice and award-winning journalism to help you optimize your working life * Nature Briefing: Microbiology — the most abundant living entities on our planet – microorganisms – and the role they play in health, the environment and food systems * Nature Briefing: Anthropocene — climate change, biodiversity, sustainability and geoengineering * Nature Briefing: AI & Robotics — 100% written by humans, of course * Nature Briefing: Cancer — a weekly newsletter written with cancer researchers in mind * Nature Briefing: Translational Research — covers biotechnology, drug discovery and pharma Please visit your preferences page to choose which Nature Briefing newsletters to receive (or to unsubscribe). ## Access Nature and 54 other Nature journals Nature+ is our most affordable 30-day subscription, giving you online access to a wide range of specialist Nature Portfolio journals, including Nature. Learn more about Nature+ | | | Join our community | | —|—|— You received this newsletter because you subscribed with the email address: ksm+healthcare@summymonkey.me Please add briefing@nature.com to your address book. Enjoying this newsletter? You can use this form to recommend it to a friend or colleague — thank you! Had enough? To unsubscribe from this Briefing, but keep receiving your other Nature Briefing newsletters, please update your subscription preferences. To stop all Nature Briefing emails forever, click here to remove your personal data from our system. Fancy a bit of a read? View our privacy policy. Forwarded by a friend? Get the Briefing straight to your inbox: subscribe for free. Want to master time management, protect your mental health and brush up on your skills? Sign up for our free short e-mail series for working scientists, Back to the lab. Get more from Nature: Register for free on nature.com to sign up for other newsletters specific to your field and email alerts from Nature Portfolio journals. Would you like to read the Briefing in other languages? Sign up for the weekly round-up e-mail in Arabic, curated and translated by the editors of Nature Arabic Edition. هل تود أن تقرأ هذا الموجز باللغة العربية؟ سَجِّل الآن لتصلك نشرة العلوم الموجزة أسبوعيًّا، التي يختار محتواها ويترجمه فريق محرري “نيتشر الطبعة العربية”. Follow Nature Portfolio on WeChat for a weekly round-up post in Chinese, curated and translated by our team in China. 关注Nature Portfolio官方微信订阅号，每周二为您推送Nature Briefing精选中文内容——自然每周简报。 Nature Portfolio | The Springer Nature Campus, 4 Crinan Street, London, N1 9XW, United Kingdom Nature Portfolio, part of Springer Nature. © 2024 Springer Nature Limited. All rights reserved. Subject:Mathematicians have described a new class of shape: soft cellss((Sender:briefing@nature.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MmM2MDU3YzUyOGZkYzZmNzNmYTE5NmQ5ZC5hYjk3NmZkMmZiLjIwMjQwOTIzMTgwNDE4LjFmZmRiYzc3YjMuNWUzYjU5NjBAbWFpbDE3Ny5zZWE1MS5tY3N2Lm5ldHx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1l9d47304a6c3017d16bcb92499e7395f0c((What matters in science | | View this email in your browser | Monday 23 September 2024 —|— | — Hello Nature readers, Today we’re introduced to a new class of shape, explore ways to tackle antimicrobial resistance and learn that part of the Three Mile Island nuclear power plant will be reopened to power Microsoft’s ambitions. The chambers of the nautilus shell can be described by 3D soft cells (James L. Amos/Getty) ## Mathematicians discover new class of shape Good news, tilers: mathematicians have described a new class of shape — soft cells. These shapes have corners that are deformed into thin points with internal angles of zero, which let them tessellate on a 2D plane with no gaps. Soft cells are common in nature, from the inside of onions to mollusc shells, but this new work is the first time they’ve been formally described. “Simply, no one has done this before,” says mathematician Chaim Goodman-Strauss. “It’s really amazing how many basic things there are to consider.” Nature | 6 min read Reference: PNAS Nexus paper ## COVID origin at Wuhan market, says study The hunt for the origins of COVID-19 has circled back to an animal market in Wuhan, China that was linked to many of the earliest cases of the disease. Researchers reanalysed genomes collected from the market shortly after it was shut down on 1 January 2020. They identified several animal species that could have passed SARS-CoV-2, the coronavirus that causes COVID-19, to people. The study establishes the presence of animals and the virus at the market, although it does not confirm whether the animals themselves were infected with the virus. The researchers argue that their reanalysis adds weight to the market being the site of the first spillover events, in which animals infected humans. Nature | 6 min read Reference: Cell paper ## AI shows flair for scientific originality An artificial intelligence (AI) ideas generator came up with more original research ideas than did 50 scientists, according to a preprint study. The ideas were blind evaluated by reviewers, who scored AI-generated concepts as more exciting, but slightly less feasible, than those from people. Critics say that pitting scientists against an LLM that can generate thousands of ideas in hours isn’t exactly a fair fight. “You have to compare apples to apples,” says computational social scientist Jevin West. Nature | 5 min read Reference: arXiv preprint (not peer reviewed) ## A scientist’s guide to personal defence Researchers have united to create a defence playbook for scholars dealing with intimidation and harassment because of their work. The advice, published by the Researcher Support Consortium, starts with steps for individuals such as removing personal information from public sites. But it also makes clear that the onus is on employers to provide support. “It’s universities and the academic institutions that have the primary responsibility to act,” says political scientist and consortium co-founder Rebekah Tromble. Nature | 5 min read ## Should kids take anti-obesity drugs? As more adults turn to anti-obesity drugs such as Ozempic and Wegovy, attention is shifting to whether they should be prescribed to children. Some of the drugs, which mimic the effects of the appetite-suppressing hormone GLP-1, are already approved in the United States and Europe to treat obesity in teenagers. Now a trial has shown that they work in children as young as six. But there is concern about whether people must stay on the medications for life to maintain the benefits. And the long-term effects of these drugs on kids’ growing bodies is unknown. Nature | 6 min read Reference: The New England Journal of Medicine paper | ## 57 days | Starting 29 September, the period during which the near-Earth object 2024 PT5 will temporarily orbit our planet — giving us, for a short time, two moons. (Reference: Research Notes of the AAS paper) —|— ## Three Mile Island nuclear plant to restart Part of the infamous Three Mile Island nuclear power plant in the United States will be reopened to power Microsoft data centres. Unit 1, which was closed in 2019, will be renamed the Crane Clean Energy Centre. Unit 2, which experienced a partial meltdown in 1979, will remain closed. It’s rare that a nuclear plant is restarted — this is only the second such programme in the United States — but the move could become more common as tech giants seek low- carbon energy sources for power-hungry artificial- intelligence (AI) systems. Microsoft has invested in an AI chatbot trained on nuclear regulations in the hopes of streamlining the multi-year process of getting a new nuclear-power plant approved. Financial Times | 5 min read & The Wall Street Journal | 6 min read (paywall) | ## ## Antimicrobial resistance — | ## How to save millions of lives Last week, we learnt that more than 39 million people could die from antibiotic-resistant infections by 2050. But it doesn’t have to be that way, argues epidemiologist Ramanan Laxminarayan — if we make sure that people in low- and middle-income countries get the appropriate antibiotics they need. “Even a fairly modest global investment — in the range of hundreds of millions of US dollars — to help prevent bacterial infections and improve access to relatively inexpensive antibiotics could avert millions of deaths,” he writes. Nature | 5 min read Reference: The Lancet report — ## Straightforward solutions to AMR Better sanitation, improved infection control practices at health-care facilities and increased vaccination are among the solutions proposed by four specialists — from Bangladesh, Brazil, Nigeria and the Middle East — who spoke to Nature ahead of a United Nations meeting on antimicrobial resistance (AMR). For example, microbiologist Iruka Okeke says that access to clean water and toilets in Nigeria could reduce gastric infections and AMR simultaneously, yielding an estimated return of US$5 or more for every $1 spent. Nature | 10 min read | ## Where I work — Forest ecologist Rebecca Hsu studies vascular epiphytes — plants that live on other plants, but do not parasitically steal their nutrients. Her research is taking her to new heights — in this case, almost 2,000 metres above ground in the canopy of a giant Taiwania tree. “Some climbers will panic, but when I reach the high tree canopy, I feel good,” she says. “Every tree climb is an adventure. You never know what you’re going to meet in the canopy until you’re there.” (Nature | 3 min read) (Dave Tacon for Nature) ## Quote of the day “When we imagine futures, we imagine dystopias. It would be nice to imagine a future where things got better.” Biologist Chris Sandom, humanities researcher Jo Waldon and artist Daniel Locke wrote and illustrated a 29-page comic, Dark Clouds, Bright Skies, envisioning what they hope a sustainable future could look like, in just 24 hours. (Comic | Leisurely scroll) | — | On Friday, Leif Penguinson was hanging out with some friends at the Retima Hippo Pool, a gathering place at the confluence of the Seronera and Orangi rivers in Tanzania’s Serengeti National Park. Did you find the penguin? When you’re ready, here’s the answer. Thanks for reading, Flora Graham, senior editor, Nature Briefing With contributions by Jacob Smith — | — ## Free newsletters from Nature Want more? Update your preferences to sign up to our other Nature Briefing newsletters: * Nature Briefing: Careers — insights, advice and award-winning journalism to help you optimize your working life * Nature Briefing: Microbiology — the most abundant living entities on our planet – microorganisms – and the role they play in health, the environment and food systems * Nature Briefing: Anthropocene — climate change, biodiversity, sustainability and geoengineering * Nature Briefing: AI & Robotics — 100% written by humans, of course * Nature Briefing: Cancer — a weekly newsletter written with cancer researchers in mind * Nature Briefing: Translational Research — covers biotechnology, drug discovery and pharma Please visit your preferences page to choose which Nature Briefing newsletters to receive (or to unsubscribe). ## Access Nature and 54 other Nature journals Nature+ is our most affordable 30-day subscription, giving you online access to a wide range of specialist Nature Portfolio journals, including Nature. Learn more about Nature+ | | | Join our community | | —|—|— You received this newsletter because you subscribed with the email address: ksm+healthcare@summymonkey.me Please add briefing@nature.com to your address book. Enjoying this newsletter? You can use this form to recommend it to a friend or colleague — thank you! Had enough? To unsubscribe from this Briefing, but keep receiving your other Nature Briefing newsletters, please update your subscription preferences. To stop all Nature Briefing emails forever, click here to remove your personal data from our system. Fancy a bit of a read? View our privacy policy. Forwarded by a friend? Get the Briefing straight to your inbox: subscribe for free. Want to master time management, protect your mental health and brush up on your skills? Sign up for our free short e-mail series for working scientists, Back to the lab. Get more from Nature: Register for free on nature.com to sign up for other newsletters specific to your field and email alerts from Nature Portfolio journals. Would you like to read the Briefing in other languages? Sign up for the weekly round-up e-mail in Arabic, curated and translated by the editors of Nature Arabic Edition. هل تود أن تقرأ هذا الموجز باللغة العربية؟ سَجِّل الآن لتصلك نشرة العلوم الموجزة أسبوعيًّا، التي يختار محتواها ويترجمه فريق محرري “نيتشر الطبعة العربية”. Follow Nature Portfolio on WeChat for a weekly round-up post in Chinese, curated and translated by our team in China. 关注Nature Portfolio官方微信订阅号，每周二为您推送Nature Briefing精选中文内容——自然每周简报。 Nature Portfolio | The Springer Nature Campus, 4 Crinan Street, London, N1 9XW, United Kingdom Nature Portfolio, part of Springer Nature. © 2024 Springer Nature Limited. All rights reserved. Subject:Why eating berries and drinking tea may lower dementia risk by 28%s((Sender:newsletter@newsletter.medicalnewstoday.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MjAyNDA5MjUxMTA1MzMuMzY4NTAwODUuOTY5MjQ0QHNhaWx0aHJ1LmNvbXx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1la6c69965e81755dc35a54456acc1325ac((New research suggests that incorporating more flavonoid-rich foods and beverages into the diet may help lower a person’s risk of dementia significantly. | | — | — | | Today’s News — Updated on September 25, 2024 at 8:00 a.m. PST | | | | | — | | Why eating berries and drinking tea may lower dementia risk by 28% — | READ ON | | | — | | | — | | Older migraine drugs more effective than some newer options, study finds — | READ ON | | | — | | | — | | Alcohol plays key role in cancer risk, new expert report warns — | READ ON | | | — | | | Read Latest news — | | — | | | | — | MNT RESOURCE — What are the differences between bipolar 1 and bipolar 2? | — A person with bipolar II may experience less severe manic episodes than with bipolar I. Learn more about the differences between these conditions here. | A person with bipolar II may experience less severe manic episodes than with bipolar I. Learn more about the differences between these conditions here. — READ ON | | — | | | | — | MNT RECOMMENDS — Best Fish Oil Supplements | — Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. | Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. — READ ON | | — | | NEW PODCAST EPISODE — In Conversation: Do tampons contain toxic metals, like lead, and are they safe? Hosted by Maria Cohut and Yasemin Nikola Sakay This podcast episode investigates whether tampons and pads pose a threat to health after a recent study found traces of heavy metals such as lead and cadmium in some menstrual products. | LISTEN TO THIS EPISODE — | | | | | | —|—|—|— | | — | | Most popular with MNT readers — | — • What is a Medicare ABN? • Minority stress model: What it is and why it is important • What are the Medicare respite care guidelines? • What to know about somatic symptom disorder • What to know about a fear of frogs | | — | | We’d love to hear from you in the meantime, so please send any feedback, comments, suggestions, or questions to the team by email. Reminder: Add newsletter@medicalnewstoday.com to your contact list so you don’t miss a single update. Kindly, The Medical News Today team — | | | | — | | | | | —|—|—|—|— You are receiving this newsletter because you subscribed on our web site, Medical News Today. Did a friend send you this email? Subscribe here. View in Browser | Privacy Policy | Unsubscribe Our website services, content, and products are for informational purposes only. Medical News Today does not provide medical advice, diagnosis, or treatment and should not be used as a substitute for medical advice from a healthcare professional. Medical News Today encourages you to make any treatment decisions with your healthcare professional. Medical News Today is owned by RVO Health. (C) 2024 RVO Health 1101 Red Ventures Drive Fort Mill, SC 29707 | | | | —|—|—|—|— Subject:Can a common diabetes drug slow aging? New study shows promises((Sender:newsletter@newsletter.medicalnewstoday.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MjAyNDA5MjMxMTA1NTAuMzY4MjMxNDguOTgyMjU1QHNhaWx0aHJ1LmNvbXx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1la403e1d7577cb335d0e2a2cfaa56da16c((The type 2 diabetes drug metformin helped slow aging across multiple organs, including the brain, kidneys, and the skin, a study in cynomolgus monkeys has shows. | | — | — | | Today’s News — Updated on September 23, 2024 at 8:00 a.m. PST | | | | | — | | Can a common diabetes drug slow aging? New study shows promise — | READ ON | | | — | | | — | | How to identify Medicare scam calls — | READ ON | | | — | | | — | | Kratom vs. CBD: What to know — | READ ON | | | — | | | Read Latest news — | | — | | | | — | MNT RESOURCE — Your FAQs around living a normal life with bipolar disorder | — As part of a well-rounded bipolar disorder treatment plan, a person may need to make certain lifestyle changes to help them manage their symptoms. Learn more here. | As part of a well-rounded bipolar disorder treatment plan, a person may need to make certain lifestyle changes to help them manage their symptoms. Learn more here. — READ ON | | — | | | | — | MNT RECOMMENDS — Best Fish Oil Supplements | — Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. | Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. — READ ON | | — | | NEW PODCAST EPISODE — In Conversation: Do tampons contain toxic metals, like lead, and are they safe? Hosted by Maria Cohut and Yasemin Nikola Sakay This podcast episode investigates whether tampons and pads pose a threat to health after a recent study found traces of heavy metals such as lead and cadmium in some menstrual products. | LISTEN TO THIS EPISODE — | | | | | | —|—|—|— | | — | | Most popular with MNT readers — | — • Decompensated vs. compensated heart failure • Massage techniques for carpal tunnel • Your guide to understanding Bardet-Biedl syndrome • Do health experts consider MRSA a STI? • What to know about diffuse large B cell lymphoma | | — | | We’d love to hear from you in the meantime, so please send any feedback, comments, suggestions, or questions to the team by email. Reminder: Add newsletter@medicalnewstoday.com to your contact list so you don’t miss a single update. 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(C) 2024 RVO Health 1101 Red Ventures Drive Fort Mill, SC 29707 | | | | —|—|—|—|— Subject:Exclusive: Two lawmakers try to preserve telehealth addiction treatments((Sender:newsletter@statnews.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MTcyNzE3MTkxNTY3OS5iNTFlOWQzMS0xODRhLTRlZDctODMzZi0xMjFhODMyMzc1NmRAYmY1MnguaHVic3BvdGVtYWlsLm5ldHx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1l0d73ab7ae1fac0cec4a4eb951cb44212c((Plus: What happened when this doctor’s mother got West Nile | September 24, 2024 — Check out STAT+ — | | — | Sponsored By — | | — | By Theresa Gaffney — Morning Rounds Writer and Podcast Producer | | Good morning, today is my nana’s 90th birthday. Happy birthday Joanie! I’m taking the day off to celebrate, so you’ll be hearing from Timmy tomorrow. — | #### exclusive # Lawmakers move to preserve telehealth addiction treatment Two Democratic lawmakers are drafting a bill to preserve the right of health providers to prescribe controlled substances like stimulants and buprenorphine via telehealth, STAT’s Lev Facher and Mario Aguilar report in an exclusive story. The news comes months before the expiration of temporary waivers first enacted by the DEA during the pandemic. “If flexibilities expire without a permanent framework of some kind of contingency plan in place, we put the care for thousands of patients at risk,” one of the lawmakers, Rep. Doris Matsui, said during a House committee meeting last week. Read more in STAT+ on where things stand. * * * ### infectious disease # CDC issues an mpox health alert for travelers The CDC is urging certain travelers to consider getting vaccinated against mpox if they are heading to countries in Eastern and Central Africa where the virus has been spreading. Doctors should recommend vaccines to those who think they may have sex with a new partner, in a commercial venue, in exchange for money, or at a large public event while in the region, the agency advised. The first of two vaccine doses should be given at least six weeks before any travel. The strain of mpox spreading in Africa — particularly in the Democratic Republic of Congo — is more severe than the strain that’s been in the U.S. since 2022. Follow STAT’s mpox coverage for more. * * * ### pharma # Is our access to cheap, effective generic drugs under threat? We’re experts on the Hatch-Waxman Act now, right? (Recap with this explainer.) It’s like the Constitution for generic drugs. Generics make up 9 out of every 10 prescriptions in the country, but experts are worried that we won’t always have access to them. In a story by our partners at Tradeoffs, experts cite three major concerns: the increasingly fragile generics supply chain, mounting quality concerns, and how hard it is to copy newer, expensive brand-name drugs. “Times have changed,” said Al Engelberg, a retired attorney who helped craft the Hatch-Waxman Act. “You have to figure out a new paradigm for new times.” Read more in STAT+. — * * * | — * * * | ### first opinion # What happened when this doctor’s mother got West Nile ##### NIAID/Wikimedia Commons Christopher Hartnick, a head and neck doctor in Boston, knows that you’re supposed to look for common causes of sickness before flipping to the pages in the textbook that cover the more far-flung possibilities. So when his mother started getting sick, he thought she may have had a stroke. But then her speech began to slur and her blood pressure fell. It took a week to identify the problem as West Nile virus. Hartnick’s mother eventually began to recover, slowly, but one symptom dogged her: “I feel like someone else,” she told her son. “I don’t feel like me.” An infectious disease colleague of Hartnick’s confirmed that this is, in fact, a well-known experience for West Nile patients. Read more in his First Opinion essay about the experience. * * * ### INJURY # Former football players who thought they had CTE saw increased suicidality Chronic traumatic encephalopathy — the brain disorder caused by repeated head injuries and more commonly known by its acronym, CTE — can only be diagnosed via an autopsy after somebody dies. But even if someone doesn’t know they have the condition, they may feel like they do, dealing with symptoms like memory loss, impaired judgment, aggression, depression, and more. A survey of more than 4,100 former football players who had a professional contract between 1960-2020 found that 34% perceived themselves to have CTE, according to a study published yesterday in JAMA Neurology. The researchers found that these men were twice as likely to report dealing with suicidality as those who didn’t think they had CTE. The data could be helpful in detecting suicidality among former football players and getting them help, the study authors wrote. If you or someone you know may be considering suicide, contact the 988 Suicide & Crisis Lifeline: call or text 988 or chat 988lifeline.org. For TTY users: Use your preferred relay service or dial 711 then 988. * * * ### climate # Q&A;: Rachel Levine on blood shortages, climate change, and gender-affirming care You may have heard there was a blood shortage this summer. There’s always a seasonal ebb and flow to blood donations, but experts also say climate change can have an effect, with extreme heat and worsening storms in certain regions keeping people away from blood banks. To understand more about the shortage, I spoke with Adm. Rachel Levine, the assistant secretary for health at the Department of Health and Human Services. Levine’s office is working to raise awareness of the importance of blood donation and the threat that climate change poses to health more broadly. In a Q&A;, Levine spoke about how climate change can impact public health and responded to a critique published in First Opinion last month that her office has not taken enough regulatory action in that arena. We also spoke about how gender-affirming care has become even more politicized since we last spoke two years ago. Read more. — * * * | More around STAT — | — | — | — | Check out more exclusive coverage with a STAT+ subscription — Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles. * * * | # What we’re reading * After suspension for sexual harassment, prominent biologist’s return to campus prompts dismay, Science * The letters of Oliver Sacks, New Yorker * Millions of people are missing from U.S. disability data, STAT * Africa sees dementia rising as people live longer, Semafor * Electronic health records giant Epic Systems sued over alleged monopolistic practices, STAT — * * * # Thanks for reading! More tomorrow, — — | | | — | theresa.gaffney@statnews.com — * * * | Enjoying Morning Rounds? Tell us about your experience — Continue reading the latest health & science news with the STAT app Download on the App Store or get it on Google Play | | — | — STAT, 1 Exchange Place, Boston, MA ©2024, All Rights Reserved. I no longer wish to receive STAT emails | Update Newsletter Preferences • Contact Us • Advertise with Us • View in Browser — Subject:Drugs like Ozempic seem to help everything from Alzheimer’s to infertility. But how?s((Sender:briefing@nature.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MmM2MDU3YzUyOGZkYzZmNzNmYTE5NmQ5ZC5hYjk3NmZkMmZiLjIwMjQwOTI1MTc0MjI0LmY2ZWM1MmY2ZjMuNTYxZjRmZGNAbWFpbDQ4LnNlYTQxLnJzZ3N2Lm5ldHx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1lb82feacce2f1336005970ff0bf2d14d8c((What matters in science | | View this email in your browser | Wednesday 25 September 2024 —|— | — Hello Nature readers, Today we grapple with the challenge of recording the numbers of dead in Gaza, learn how scientists are building giant ‘evidence banks’ to create policies that actually work and explore the mysterious mechanisms that underpin spectacularly successful obesity drugs. The Palestinian Ministry of Health — Gaza had based records on deaths reported at hospitals, but after medical centres came under attack, the ministry has had to increasingly rely on reports by the Palestinian Civil Defence, the Palestine Red Crescent Society, ministry staff or close relatives. (Reuters/Mohammed Salem) ## The difficulty of counting deaths in Gaza Since Israel began military operations in the Gaza Strip in response to the attacks of 7 October 2023 carried out by Hamas, the official number of Palestinians killed has exceeded 41,000. The count comes from the local ministry of health and the number has been challenged as both an over- and under-estimate. It’s important to track fatalities to hold warring parties accountable and to advocate for the protection of civilians, says epidemiologist Zeina Jamaluddine. But with much of the population displaced and some entire families being wiped out with no one left to report the loss, some deaths are not being counted, says Emily Tripp, director of the non- profit watchdog Airwars. Only when the conflict ends or eases can researchers begin the work of getting more robust estimates of overall mortality through surveys, modelling and statistical tools, they say. Nature | 7 min read ## Sleuths flag 130 papers by one author A team of scientist–sleuths has flagged data-integrity concerns in 130 studies authored by the same researcher, a specialist in women’s health and gynaecology, and his colleagues. Published between 2014 and 2023, the problems with the studies included oddities in reported statistics, unfeasible results and text that is identical to other papers. Some of the studies that were identified as potentially problematic have been included in analyses that could inform clinical practice, with potentially harmful consequences. Nature | 9 min read Reference: Journal of Gynecology Obstetrics and Human Reproduction paper ## Youth depression differs in the brain Regions of the brain in young people with severe depression are disrupted in different ways to adults with the condition. A mega-analysis of brain scans showed that connectivity was stronger in some parts of the brain in people aged 12-25 with major depressive disorder than in people without it, and weaker in others. Connectivity in the area of the brain associated with internalized thoughts was particularly strong. “While there is some overlap with the connectivity disruptions that we see in adults, there are also unique and specific circuit disruptions that we only see in youth with depression,” says neuroscientist Andrew Zalesky. The Guardian | 4 min read Reference: Nature Mental Health paper ## Giant ‘evidence banks’ for policies that work Funders are investing US$70 million into a plan to solve the problem of supplying evidence to governments. Their goal is to build a system that allows policymakers worldwide to quickly synthesize scientific evidence to help them develop policies on issues like climate change. Evidence syntheses are “everything the world knows about how to solve an important problem in one place”, says Will Moy, lead of the Campbell Collaboration. They’re routinely used in health, but not in other areas of policymaking. It can take years to extract meaning from a massive body of research. Nature | 6 min read | ## Brain–computer interfaces — ## The state of brain-implant clinical trials Implanted brain–computer interfaces (BCIs) have demonstrated tantalizing successes in restoring speech, movement or touch perception to paralyzed people in clinical trials. But, despite trials running since 1998, not one BCI has been approved by regulatory agencies for the medical device market. And there is no central repository for information on BCI research. To address this gap, three BCI researchers have conducted a review of trials up to 2023, including this very useful graphical timeline. They also suggest ways in which the sector needs to improve — such as by dealing with the considerable underrepresentation of women as trial participants. Nature Reviews Bioengineering | 52 min read Read more: A collection of articles in Nature Reviews Bioengineering address the promise and challenges of neurotechnologies — including brain interfaces and non-invasive brain stimulation. ## Webinar Neurotechnology researcher and co-author Jose Contreras-Vidal and Mariska Vansteensel, an expert in conducting clinical trials of implanted BCIs, will talk to Nature Reviews Bioengineering editor Sadra Bakhshandeh about this much-awaited review article on Wednesday 9 October. Join the conversation in a free webinar — register here. | ## Features & opinion — ## Obesity drugs treat so much — but how? Evidence is growing that drugs such as Ozempic and Wegovy, which mimic the effects of the hormone GLP-1, have broad therapeutic benefits. They seem to reduce the risk of cardiovascular problems, slow the development of Parkinson’s disease and even suppress addiction in the same way they suppress appetite. But in a lot of cases, we still need to figure out one crucial piece of information: why they work. “If you are trying to capitalize on a possible therapeutic effect and make the next generation of a drug even better, then you ought to know where it is working and how it is working,” says endocrinologist Daniel Drucker. Nature | 13 min read ## We need more botanists and zoologists The decline in the teaching of species-classification skills could derail efforts to support conservation, argues ecologist Dasheng Liu. “A lack of taxonomic knowledge, especially at the local level, is leading to errors,” he writes. “For example, in 2022, a common fish in Xiaoqing River, China, was mistakenly reported to be an endangered species, causing confusion among conservationists and the public.” He calls for the Kunming Biodiversity Fund — aimed at supporting global biodiversity conservation in low- and middle-income countries — to include a substantial pot of money for biodiversity education. Nature | 5 min read ## Quote of the day “I’m still waiting for my ride on a space elevator, but in the meantime, I’ll take comfort in the fact that graphene is already helping to shape a better future.” Chemical engineer Stephen Lyth argues that while some of its more outlandish potential uses haven’t come to fruition, ‘wonder material’ graphene is still revolutionizing science almost 20 years after it was first described. (The Conversation | 5 min read) | — | Today I’m delighted that scientists are working to protect one of life’s great pleasures: really good olive oil. Researchers brought nuclear magnetic resonance to bear on samples of virgin olive oil spiked with varying percentages of other oils. They created spectroscopic profiles of the oils that can be used to quickly determine whether the good stuff has been adulterated — and even the concentrations of each unwelcome ingredient. While I prepare something nice to dip and drizzle, why not send me your favourite olive-oil recipes — plus any feedback on this newsletter — to briefing@nature.com. Thanks for reading, Flora Graham, senior editor, Nature Briefing With contributions by Jacob Smith and Smriti Mallapaty — | — ## Free newsletters from Nature Want more? 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Get more from Nature: Register for free on nature.com to sign up for other newsletters specific to your field and email alerts from Nature Portfolio journals. Would you like to read the Briefing in other languages? Sign up for the weekly round-up e-mail in Arabic, curated and translated by the editors of Nature Arabic Edition. هل تود أن تقرأ هذا الموجز باللغة العربية؟ سَجِّل الآن لتصلك نشرة العلوم الموجزة أسبوعيًّا، التي يختار محتواها ويترجمه فريق محرري “نيتشر الطبعة العربية”. Follow Nature Portfolio on WeChat for a weekly round-up post in Chinese, curated and translated by our team in China. 关注Nature Portfolio官方微信订阅号，每周二为您推送Nature Briefing精选中文内容——自然每周简报。 Nature Portfolio | The Springer Nature Campus, 4 Crinan Street, London, N1 9XW, United Kingdom Nature Portfolio, part of Springer Nature. © 2024 Springer Nature Limited. All rights reserved. Subject:Can Anne Wojcicki save 23andMe?s((Sender:newsletter@statnews.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MTcyNzI1ODgwNTAzNy4zYjYzZDc1MC01YmZkLTQ3YWMtOThlOS04NjdlMDg3MjVjNmRAYmY1MnguaHVic3BvdGVtYWlsLm5ldHx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1la45de9f07ff8a9524a2409b9968af5e7c((Plus surprising data on cancer diagnoses post-Covid | September 25, 2024 — Check out STAT+ — | | — | Sponsored By — | | — | By Timmy Broderick — Disability in Health Care Reporting Fellow | | Good morning! What are your autumn rituals? Every fall I try to catch a falling leaf. I know, it’s very twee, but I love seasonal ceremonies. And I did it! I caught a falling leaf while biking to the ocean on Sunday. Happy fall, y’all. — | ### matt’s take # What’s the future of 23andMe in 2024? ##### Illustration: Alex Hogan/STAT, photo: Milken Do healthy people care about their DNA at all? That’s the question at the heart of Matthew Herper’s story on 23andMe. It’s also the question facing the embattled genetics-testing company after every member of its board of directors — except 23andMe CEO and co-founder Anne Wojcicki — quit last week. The company has endured catastrophic losses since its initial $3.5 billion public offering in 2021, prompting Wojcicki to try to cobble together investors to take the company private again. But the board did not believe in her plan. And now, as Matt explains, it’s unclear if anyone wants to help Wojcicki pick up the pieces again. Come for the story about Matt’s memorable lunch with Wojcicki at a Brazilian sandwich shop; stay for the nuanced and thought-provoking look at why investors have soured on a company that turned genetic testing into a cultural phenomenon. * * * ### cancer # Unexpected data on post-pandemic cancer diagnoses Remember when the world shut down in early 2020? With checkups on hold during the first wave of Covid-19, people weren’t getting their screening mammograms or colonoscopies. A precipitous drop in all cancer screening was matched by a plunge in cancer diagnoses, a dive experts predicted might lead to 10,000 excess deaths in the U.S. over the next 10 years, just from breast and colorectal cancer. It’s too soon to breathe a sigh of relief, but newly released data shows that an uptick in new diagnoses, including at a later stage, so far hasn’t materialized across all cancer types. Looking to see if missed diagnoses from 2020 surfaced in 2021, researchers found that diagnoses are back to pre- pandemic levels, with no significant rebound to account for 2020’s drop. An exception: New diagnoses of metastatic breast cancer went up in 2021, per Tuesday’s study in the Journal of Clinical Oncology. The authors caution “continuous monitoring is necessary.” — Liz Cooney * * * ### disability # How the Special Olympics began the push for better disability data What do Yale, Boyz II Men, Hillary Clinton and a steady stream of athletes sent to the ER have in common? That’s right, you guessed it: The 1995 Special Olympics. That year, officials debuted Healthy Athletes, a program to improve health care for the competitors with intellectual and developmental disabilities. The program also kick-started an ongoing movement to improve the health and demographic data for this population, and for all people with disabilities. As I write in the story, the missing data is about more than an empty box on a patient’s chart. It puts lives at risk. During the pandemic, people with these disabilities were 2.6 times more likely to die from Covid-19 than people without one, but the data gap thwarted attempts to address this disparity. Read more about how researchers and activists have been pushing for more robust data for decades, and why this will help everyone. — * * * | — * * * | ### first opinion # Veterinarians can help combat antimicrobial resistance ##### ALASTAIR PIKE/AFP via Getty Images On Thursday, the U.N. General Assembly will discuss the global threat of antimicrobial resistance. While scientists have known about antimicrobial resistance since penicillin entered the market in the 1940s, veterinarian and pathobiologist Scott Weese says that the antibiotics fed to animals are an overlooked part of the conversation. Veterinarians desperately need official guidance on antibiotic use in animals so that they can ethically treat animals while also responsibly curbing their contributions to this global resistance. The impact of the problem is immense. A recent analysis published in The Lancet estimated that AMR was directly responsible for 1.3 million deaths and contributed to nearly 5 million more globally in 2019 alone. Read more. * * * ### reproductive health # Pregnancy-related arrests on the rise post-Dobbs I learned the phrase “pregnancy criminalization” yesterday after reading a new report that at least 210 pregnant people faced criminal charges associated with pregnancy in the first year after the Supreme Court’s Dobbs decision. That’s the highest number of people to face such charges in one year since 1973, when researchers began tracking, according to Pregnancy Justice, the nonprofit that published the report. The majority of cases occurred in states that have severely restricted abortion access and enshrined fetal personhood protections in their laws, including Alabama and Oklahoma. The charges brought against the pregnant people ranged from child neglect, abuse, or endangerment to murder, but most cases only required a perceived risk of harm, rather than “proof” of harm to the fetus or baby. The report’s authors note of cases involving substance use that “criminalizing substance use and pregnancy deters pregnant people from seeking healthcare and actually increases risks to maternal, child, and fetal health.” — * * * | More around STAT — | — | — | — | Check out more exclusive coverage with a STAT+ subscription — Read premium in-depth biotech, pharma, policy, and life science coverage and analysis with all of our STAT+ articles. * * * | # What we’re reading * ​​Tony Robbins was reeling from backlash. Then came an unlikely ally: Stanford, San Francisco Chronicle * Sanders says PBMs won’t penalize Novo for cutting Ozempic, Wegovy prices, STAT * 1 in 7 scientific papers is fake, says one researcher, Retraction Watch * How the next president should reform Medicare, STAT * Retired NFL quarterback Brett Favre says he has Parkinson’s disease, AP — * * * # Thanks for reading! More tomorrow — Timmy — | | | — | timmy.broderick@statnews.com — * * * | Enjoying Morning Rounds? Tell us about your experience — Continue reading the latest health & science news with the STAT app Download on the App Store or get it on Google Play | | — | — STAT, 1 Exchange Place, Boston, MA ©2024, All Rights Reserved. I no longer wish to receive STAT emails | Update Newsletter Preferences • Contact Us • Advertise with Us • View in Browser — Subject:👧🏻 Kids falling through crackss((Sender:vitals@axios.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MjAyNDA5MjUwNjE0MjYuMzY4NDU3OTMuNzM0MzRAc2FpbHRocnUuY29tfHxja3NtK2hlYWx0aGNhcmVAc3VtbXltb25rZXkubWU=99138f2ee6eed9f84024102be36a4e93c((Plus: Drug price hearing surprise | Wednesday, September 25, 2024 | — | | Open in app View in browser —|— Presented By the Coalition to Strengthen America’s Healthcare Axios Vitals By Maya Goldman and Tina Reed * Sep 25, 2024 Halfway there, gang. Today’s newsletter is 993 words or a 3.5-minute read. 1 big thing: Kids fall through health safety net By Maya Goldman Illustration: Maura Losch/Axios The number of kids enrolled in Medicaid has decreased by more than 5.5 million in the last 18 months, and only a small number of those losing coverage were enrolled in a sister program designed to be a safety net for uninsured children. Why it matters: It illustrates how paperwork hassles, technicalities and differing state policies create significant coverage gaps among working-class families as states finish purging their Medicaid programs now that pandemic- era coverage requirements have ended. The big picture: The Children’s Health Insurance Program was designed to keep kids insured when their family makes too much to qualify for Medicaid but still might have trouble affording private health insurance. * The Urban Institute in 2022 estimated that 57% of kids losing Medicaid in state unwindings would be eligible for separate CHIP coverage. * Instead, CHIP programs have netted up about 9% — or 450,000 — of the population of kids who fell off Medicaid rolls since states started resuming eligibility checks in the spring of 2023, according to a Georgetown University analysis of state and federal data shared with Axios. * Millions of other kids who were dropped are eligible for CHIP but are believed to have slipped through the cracks due to paperwork issues or some states’ failure to automatically transfer enrollees between the programs. Catch up quick: Like Medicaid, the criteria for CHIP programs varies by state. There are different income eligibility levels, and some states require recipients to pay monthly premiums. * The differences have left a patchwork of coverage options with significant gaps in the safety net. * Enrollment in Connecticut’s CHIP program increased by about 60% of the state’s Medicaid enrollment decline. * But other states lag far behind. Michigan saw only a 0.1% increase while Idaho’s CHIP enrollment decreased between the start of Medicaid unwinding and February 2024. Read more 2. Ozempic maker’s CEO blames insurers for prices By April Rubin Jørgensen testifying at the Senate health committee. Photo: Al Drago/Bloomberg via Getty Images The chief executive of the company behind Ozempic and Wegovy blamed insurers and middlemen for the high costs of weight-loss drugs in the U.S. during a Senate hearing on Tuesday. Why it matters: Lars Fruergaard Jørgensen, who leads Novo Nordisk, passed along accountability for access to the blockbuster treatments while being questioned about his company’s role in setting prices. * “We don’t decide the price for patients. That is set by the insurance companies,” Jørgensen said. Context: Sen. Bernie Sanders (I-Vt.), chair of the Senate health committee, has outlined concerns that the high costs of these drugs could bankrupt Medicare and drive up insurance premiums. * “All we are saying, Mr. Jørgensen, is treat the American people the same way that you treat people all over the world,” Sanders said on Tuesday. “Stop ripping us off.” * Sanders had a surprise waiting, announcing that he had received commitments in writing from the three major pharmacy benefit managers that they would not reduce coverage of Ozempic or Wegovy if Novo Nordisk cut the list price, Peter Sullivan wrote first on Pro. * Sanders pressed Jørgensen to commit to talk with the PBMs to work out a way to lower the price, which the CEO appeared open to doing, albeit with a note of skepticism. Read more If you need smart, quick intel on health care policy for your job, get Axios Pro Policy. 3. 988 begins routing calls based on location By Maya Goldman Illustration: Eniola Odetunde/Axios The 988 national suicide hotline has started routing calls to answering centers based on the location of the call, HHS announced Wednesday. Why it matters: Since its launch in 2022, calls to 988 have been routed to crisis centers based on area code. But many people keep their cellphone number after moving to a new region. * Georouting — the process of connecting calls to crisis centers based on their location — puts callers in touch with counselors more familiar with what local resources are available. * “Georouting will be crucial to make sure that we’re not only responding well, but responding quickly and appropriately,” HHS Secretary Xavier Becerra told reporters Tuesday. State of play: Verizon and T-Mobile voluntarily started georouting 988 calls last week, officials said. The federal government is also working with AT&T; and expects the carrier to start georouting in the next month. * Location data does not show the exact location of the caller and instead is generalized to a broader area, then passed along to the closest call center, officials said. * The georouting does not yet apply to text messages sent to 988. Share this A message from the Coalition to Strengthen America’s Healthcare The truth about Medicare Advantage Some corporate Medicare Advantage insurers are adding administrative hurdles to delay and deny access to necessary patient care while raking in profits. Get the facts on why it’s time to hold corporate Medicare Advantage insurers accountable. 4. AI’s new trick: ID old drugs for rare diseases By Tina Reed Illustration: Aïda Amer/Axios A new artificial intelligence tool could supercharge efforts to find new uses for old drugs, particularly rare diseases without an FDA- approved treatment. The big picture: The Harvard Medical School researchers behind the tool, called TxGNN, write today in Nature Medicine that it can identify candidates for 17,000 conditions — the largest number of diseases that any single AI model has handled to date. * The team is making the tool available for free to spur more research on untreated or undertreated conditions that affect 300 million people worldwide. Details: The tool has two features: one that identifies drug candidates and possible side effects and another that explains the rationale for the decision. * It identified drug candidates from nearly 8,000 medicines, including those that are already approved and those still in trials. Between the lines: There are other tools on the market that ID drugs that can be repurposed. But the process often is “serendipitous and opportunistic,” the researchers write. * The Harvard- developed tool was 50% better on average at identifying drug candidates compared against the leading AI models and 35% more accurate in predicting what drugs would have potentially harmful effects. More here 5. Catch up quick 🌍 President Biden announced the U.S. is donating 1 million mpox vaccine doses and at least $500 million to African countries to support their response to the outbreak. (Reuters) 📒 Between June 2022 and June 2023, there were more than 200 cases in which a pregnant person faced criminal charges for conduct associated with pregnancy, pregnancy loss or birth, per a civil rights nonprofit. (CNN) 🏈 Hall of Fame quarterback Brett Favre revealed during a congressional hearing that he was recently diagnosed with Parkinson’s disease. (Yahoo) A message from the Coalition to Strengthen America’s Healthcare The truth about Medicare Advantage Some corporate Medicare Advantage insurers are adding administrative hurdles to delay and deny access to necessary patient care while raking in profits. Get the facts on why it’s time to hold corporate Medicare Advantage insurers accountable. Thanks for reading Axios Vitals, and to senior health care editor Adriel Bettelheim, managing editor Alison Snyder and copy editor Matt Piper. Please ask your friends and colleagues to sign up. | | | Dive deeper into the future of health care Axios Pro is your personal health care industry analyst, here to help you make the news actionable and anticipate future outcomes. Subscribe today. — — Axios thanks our partners for supporting our newsletters. Sponsorship has no influence on editorial content. Advertise with us. Axios, PO Box 101060, Arlington VA 22201 You received this email because you signed up for newsletters from Axios. 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Healthcare Sep 04 2024 — | TOP NEWS — In Focus UAE diagnostic labs market to be valued at $1.46b by 2029 Key drivers include investments in advanced technologies and government support. | Global immunology market to grow by $65.8b by 2028 It is driven by advancements in organ transplantation and a strong pipeline of immunological agents. South Korean PCR systems market to grow at 5% CAGR through 2033 A key factor is Seegene’s recent launch of a specialised PCR test in South Korea. Radiopharmaceutical market for prostate cancer to reach $6.3b by 2030 Radioligand therapies are gaining significant traction in the treatment of prostate cancer.The radiopharmaceutical market for prostate cancer is projected to reach $6.3b by 2030. What’s driving the non-muscle- invasive bladder cancer market? It is driven by a surge in NMIBC cases. Home infusion therapy market to grow to $71.82b by 2032 It is driven by the aging population and a rise in chronic diseases. Australia invests $2.6b to raise aged care worker pay by 2025 The pay increases will take effect from 1 January 2025. Samitivej Hospital and Mahidol University ink MoU for carbon neutrality The hospital aims to achieve net zero greenhouse gas emissions by 2050. — | CO-WRITTEN ARTICLES & SPONSORED CONTENT Digital Healthcare Reforms Will Benefit Providers Explore Investment Opportunities and Cutting-edge Innovations at International Healthcare Week in Hong Kong this May Why rare disease policies are critical to ensure equitable access to treatment for rare disease communities in Southeast Asia Medical Taiwan 2023: Digital Healthcare, Innovation, and Sustainability — | PRINT ISSUE Healthcare Asia (HCA) is the industry magazine serving Asia’s hospital owners, investors, administrators and policy makers. 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Situational awareness: Novo Nordisk CEO Lars Fruergaard Jørgensen is due to testify before the Senate health committee and its Chair Bernie Sanders this morning about the costs of the company’s Ozempic and Wegovy. 1 big thing: Minority docs’ outsize Medicaid load By Tina Reed Illustration: Megan Robinson/Axios Doctors of color may be bearing a disproportionate burden caring for patients most in need, with Black and Latino physicians far likelier to accept Medicaid than their white peers, new research shows. Why it matters: The findings provide compelling evidence that race and ethnicity are directly connected to participation in the safety net program, and that diversity in the health care workforce is needed to address inequities. * And they underscore how a small subset of primary care doctors may be caring for many of the poorest, sickest patients. In 2022, just 5% of active physicians identified themselves as Black and approximately 7% as Latino, Hispanic or of Spanish origin. The big picture: Despite efforts to expand access to care through Medicaid, which now covers almost 74 million people, beneficiaries can still face significant barriers finding a doctor. * Doctors may be hesitant to accept Medicaid patients because of poor reimbursement rates, administrative hassles getting paid or a fear that they require more complex care, said Anushree Vichare, lead author of the study. What they found: The George Washington University-led researchers found roughly half of family physicians had a significant number of Medicaid beneficiaries — defined as 150 or more — under their care. * However, by linking unique data on physician race and ethnicity against 2016 Medicaid claims from more than 13,000 doctors, they found those who identified as Black had a 60% increase in the likelihood of accepting a significant number of Medicaid patients. Those who were Latino had a 40% increased likelihood. * The study also found Black and Latino doctors tended to have higher overall numbers of Medicaid patients under their care than a reference group of white doctors. Zoom in: The study comes as minority representation may lag further due to the recent Supreme Court decision on affirmative action. Read more 2. Health records giant faces antitrust suit By Maya Goldman Illustration: Aïda Amer/Axios Health data startup Particle Health sued electronic health records giant Epic Systems for federal antitrust violations on Monday, charging it uses its control over troves of patient records to stifle competition. Why it matters: About 36% of hospitals use Epic for their EHRs, and Particle estimates in its lawsuit that as many as 94% of American patients have at least one record stored in an Epic EHR. State of play: Payer platforms like Particle digitize the process of retrieving medical records and analyzing their data. Insurers have traditionally done this manually. * Epic has its own platform. The lawsuit charges that Epic purposely “made it commercially impossible” for rivals to access records stored in Epic EHR software. Zoom in: Particle claims Epic started retaliating against the company after it found a way to circumvent Epic’s block on other payer platforms. * Federal regulations require Epic and its competitors to make their records available in response to requests concerning health treatment. * Particle realized in 2023 that payers are increasingly involved in actual services offered to its members. This allowed Particle to help payers access records for treatment decisions and then use them for purposes like health analytics, the lawsuit claims. * Epic’s actions are anticompetitive and a violation of antitrust laws, according to the complaint, which seeks monetary damages and injunctive relief. Read more 3. Opioid abuse meds don’t reach neediest areas By Adriel Bettelheim Illustration: Shoshana Gordon/Axios Nearly 1 in 5 U.S. counties lacked opioid treatment programs or any office- based providers of buprenorphine, which reduces the risk of future overdoses, according to a federal review of whether drugs for opioid abuse are reaching areas of greatest need. Why it matters: It’s the latest sign that many Americans in the throes of the addiction crisis aren’t getting access to potentially life-saving treatments. What they found: In 2022, individuals seeking treatment — including those enrolled in Medicare or Medicaid — often face hurdles finding providers allowed to prescribe and dispense drugs for opioid use disorder, the HHS inspector general’s review found. * Even in counties with services, providers often did not treat Medicare or Medicaid enrollees. * Medicare Advantage prior authorization requirements, low Medicaid reimbursement rates and inadequate public information about provider locations all contribute to the barriers, per the review. By the numbers: 597 of the 3,143 U.S. counties nationwide (19%) did not have any office-based buprenorphine providers or opioid treatment programs in 2022. * 26% of counties in high need of services based on their overdose death rates had few or no providers. * 32% of all U.S. counties and 19% of all high-need counties lacked providers that treated either Medicare or Medicaid enrollees. Go deeper A message from the Coalition to Strengthen America’s Healthcare Some corporate insurers are putting rural healthcare at risk Medicare Advantage is delaying and denying patient care, shrinking provider networks, and underpaying hospitals — making it harder for some rural patients to get care. Nearly 150 rural hospitals have closed, with hundreds more at risk, while corporate insurers bank record profits. Learn more. 4. Senate Dems force emergency abortion vote By Stephen Neukam Schumer (D-N.Y.) at the U.S. Capitol. Photo: Kevin Dietsch/Getty Images Top Senate Democrats will force Republicans to vote on access to emergency abortion care this week, in one of Senate Majority Leader Chuck Schumer’s final pre-election messaging pushes. The big picture: The death of a Georgia woman who was refused emergency care because of the state’s abortion restrictions has become the latest rallying cry for Democrats who are wagering abortion will be a winning issue for their party on Nov. 5. * Sen. Patty Murray (D-Wash.), will seek unanimous consent Tuesday to pass a resolution she introduced last week affirming that every person has a right to emergency health care, including abortion care. * Murray’s move will force Republicans to either block the measure or pass it. * Sen. Tammy Baldwin (D-Wisc.) also will seek unanimous consent Tuesday on a bill that would offset travel costs for people seeking abortion care. Catch up quick: An investigation published by ProPublica last week highlighted the circumstances of Amber Nicole Thurman’s 2022 death — the first publicly reported death caused by delayed abortion care. Zoom in: The maneuvers represent Senate Democrats’ parting shots in their messaging war with with Republicans before lawmakers go home to campaign ahead of Election Day. More here 5. Catch up quick 👀 A mysterious anti-pharma bus tour fueled by dark money is barnstorming swing states. (Stat) ⚡️ An AstraZeneca drug failed to significantly extend the lives of breast cancer patients, in a blow to the company’s goals to hit an $80 billion revenue target by 2030. (FT) ⚕️ Women bear a disproportionate amount of pain over the course of their lives but their concerns are dismissed or downplayed by health providers. (The Hill) A message from the Coalition to Strengthen America’s Healthcare Some corporate insurers are putting rural healthcare at risk Medicare Advantage is delaying and denying patient care, shrinking provider networks, and underpaying hospitals — making it harder for some rural patients to get care. Nearly 150 rural hospitals have closed, with hundreds more at risk, while corporate insurers bank record profits. Learn more. Thanks for reading Axios Vitals, and to senior health care editor Adriel Bettelheim, managing editor Alison Snyder and copy editor Matt Piper. Please ask your friends and colleagues to sign up. | | | Dive deeper into the future of health care Axios Pro is your personal health care industry analyst, here to help you make the news actionable and anticipate future outcomes. Subscribe today. — — Axios thanks our partners for supporting our newsletters. Sponsorship has no influence on editorial content. Advertise with us. Axios, PO Box 101060, Arlington VA 22201 You received this email because you signed up for newsletters from Axios. To stop receiving this newsletter, unsubscribe or manage your email preferences. Was this email forwarded to you? Sign up now to get Axios in your inbox. Follow Axios on social media: Subject:Microplastics found in brain’s smell center: Could it affect health?s((Sender:newsletter@newsletter.medicalnewstoday.comD))chatlink:https://summymonkey.me/wp-json/chatlink/v1/sm-chat?chat=MjAyNDA5MjQxMTA1MzcuMzY4MzY5MTYuOTY3MjUzQHNhaWx0aHJ1LmNvbXx8Y2tzbStoZWFsdGhjYXJlQHN1bW15bW9ua2V5Lm1lc9f01908312dfe54a7f21021abc7b275c((Researchers have found evidence of microplastics in the olfactory bulbs of the human brain for the first time, after detecting them in the colon and the bloodstream. | | — | — | | Today’s News — Updated on September 24, 2024 at 8:00 a.m. PST | | | | | — | | Microplastics found in brain’s smell center: Could it affect health? — | READ ON | | | — | | | — | | Shifts in brain activity may signal Alzheimer’s long before symptoms appear — | READ ON | | | — | | | — | | EBGLYSS for eczema: What to know about the newly FDA-approved drug from Eli Lilly — | READ ON | | | — | | | Read Latest news — | | — | | | | — | MNT RESOURCE — Understanding the progression of Crohn’s disease | — Symptoms of Crohn’s disease may become more severe over time due to levels of inflammation in the intestines and throughout the body. Here’s what the progression of Crohn’s may look like. | Symptoms of Crohn’s disease may become more severe over time due to levels of inflammation in the intestines and throughout the body. Here’s what the progression of Crohn’s may look like. — READ ON | | — | | | | — | MNT RECOMMENDS — Best Fish Oil Supplements | — Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. | Fish oil may have various health benefits, but does the evidence support this? Read on for some options to consider. — READ ON | | — | | NEW PODCAST EPISODE — In Conversation: Do tampons contain toxic metals, like lead, and are they safe? 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